Enhanced skin localization of doxycycline using microparticles and hydrogel: Effect of oleic acid as penetration enhancer

One of the disadvantages gel preparations is poor ability to penetrate skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based containing microparticle doxycycline hyclate (DOX). Oleic acid (OA) was added into formulation specifically increase penetrability DOX microparticles. The objective this work determine effect varying concentration OA on physical characteristics, penetration and retention abilities DOX. microparticles were initially prepared using PLGA as matrix then incorporated NaCMC-based with various concentrations: 0%, 2.5%, 5%, 7.5%, 10% for F1, F2, F3, F4, F5, respectively. evaluated their organoleptic test, homogeneity, pH measurement, viscosity, spreadability, well ex vivo abilities. characteristics tests revealed homogeneous yellow distinctive odor values compatible requirements human test showed retained 1236.46 µg in Finally, skin from loaded significantly higher compared free gel, indicating can be extremely effective retaining infected area.